In my practice, I work with a lot of clients in their 40s, 50s, and 60s who are frustrated that the skincare routine that worked beautifully in their 30s no longer seems to be cutting it. There's a biological reason for that — and growth factors are a large part of the solution.
What Happens to Skin After 40
Starting in our mid-30s and accelerating through our 40s and 50s, the skin undergoes a cascade of changes driven by declining hormone levels and slowing cellular communication. Collagen production drops by roughly 1% per year after age 20, and the rate of cell turnover slows significantly. The result: skin that's thinner, less elastic, slower to heal, and less responsive to the products that once worked.
Critically, growth factor production also declines with age — which means the biological signals that tell skin cells to produce collagen, repair damage, and maintain density become quieter. This is where topical growth factors can make a meaningful difference.
What Growth Factors Do for Mature Skin Specifically
When applied topically to mature skin, growth factors essentially turn up the volume on cellular communication that has grown quieter with age. Clinical studies on growth factor serums in mature skin populations have shown improvements in skin density and thickness, reduction in fine line depth, improvements in skin firmness and elasticity, and accelerated healing of UV-induced damage. These are not cosmetic surface effects — they're changes in how the skin actually functions at a cellular level.
How to Integrate Growth Factors into a Mature Skin Routine
Apply a growth factor serum after cleansing and toning, before your moisturizer. Morning or evening use is effective, though I often recommend evening as part of the skin's natural nighttime repair cycle. Growth factors layer beautifully with peptides, hyaluronic acid, and retinol — in fact, the combination of growth factors and a retinoid is one of the most powerful anti-aging pairings you can build.
Our Growth Factor Peptide Fusion Serum pairs human growth factors with a multi-peptide complex and antioxidant botanicals for a comprehensive mature skin protocol that visibly restores density, firmness, and radiance.
Your skin's most important decade of care starts now. Shop the Growth Factor Peptide Fusion here.